There are two departure flightpaths that have CAA airspace approval. One is to the west (runway 25) and the other is to the east (runway 7).

Runway 25

Runway 7
In both cases the vast majority of departing flights turn south about 2 miles or so after leaving the runway to head for the route to their final destination. There are some exceptions, but the turn south is the default. In both cases, the flight paths overfly residential areas at low altitude.
Aircraft always take off into the wind to take advantage of the additional lift. 70% of the year, the dominant wind direction is westerly – from the west. In these conditions, aircraft start their take off at the eastern end of the runway and accelerate westwards before becoming airborne. When the wind is from the east the other 30% of the time, the reverse is true.
Aircraft always land into the wind. There are two approved arrival flightpaths – east and west. When the wind is westerly, aircraft line up with the runway out over the North Sea. When it’s easterly, aircraft line up with the runway down the Tyne Valley.
The arrival flightpaths are not the reverse of the departure flightpaths
The runway as it is now

The runway extension to the east of the Airport
If the Airport's Masterplan 2040 is implemented as is, this is what the changes to the runways will look like. The main disruption from construction will affect people living to the east of the Airport.
The extension will mean that larger and heavier aircraft than at present will be able to fly to and from the Airport to more distant destinations.